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Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain.

Authors
  • Darnell, R B1
  • 1 Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, 10021, USA.
Type
Published Article
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publication Date
May 14, 1996
Volume
93
Issue
10
Pages
4529–4536
Identifiers
PMID: 8643438
Source
Medline
License
Unknown

Abstract

Paraneoplastic neurologic disorders (PNDs) are believed to be autoimmune neuronal degenerations that develop in some patients with systemic cancer. A series of genes encoding previously undiscovered neuronal proteins have been cloned using antiserum from PND patients. Identification of these onconeural antigens suggests a reclassification of the disorders into four groups: those in which neuromuscular junction proteins, nerve terminal/vesicle-associated proteins, neuronal RNA binding proteins, or neuronal signal-transduction proteins serve as target antigens. This review considers insights into basic neurobiology, tumor immunology, and autoimmune neuronal degeneration offered by the characterization of the onconeural antigens.

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