Affordable Access

deepdyve-link
Publisher Website

Oncocytic Adrenocortical Carcinoma With Low 18F-FDG Uptake and the Absence of Glucose Transporter 1 Expression

Authors
  • Babaya, Naru1
  • Noso, Shinsuke1
  • Hiromine, Yoshihisa1
  • Taketomo, Yasunori1
  • Niwano, Fumimaru1
  • Monobe, Keisuke1
  • Imamura, Shuzo1
  • Ueda, Kazuki2
  • Yamazaki, Yuto3
  • Sasano, Hironobu3
  • Ikegami, Hiroshi1
  • 1 Department of Endocrinology, Metabolism and Diabetes, Kindai University Faculty of Medicine, Osaka-sayama, Osaka 589-8511 , (Japan)
  • 2 Department of Surgery, Kindai University Faculty of Medicine, Osaka-sayama, Osaka 589-8511 , (Japan)
  • 3 Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575 , (Japan)
Type
Published Article
Journal
Journal of the Endocrine Society
Publisher
The Endocrine Society
Publication Date
Aug 23, 2021
Volume
5
Issue
11
Identifiers
DOI: 10.1210/jendso/bvab143
PMID: 34514280
PMCID: PMC8423427
Source
PubMed Central
Keywords
Disciplines
  • AcademicSubjects/MED00250
License
Unknown

Abstract

Adrenocortical carcinoma (ACC) is a rare tumor, and some histological variants (oncocytic, myxoid, and sarcomatoid ACCs) have been reported in addition to the conventional ACC. Among these subtypes, oncocytic ACC is histologically characterized by the presence of abundant eosinophilic granular cytoplasm in the carcinoma cells owing to the accumulation of mitochondria, which generally yields high 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET). Herein, we report the case of a 21-year-old woman with oncocytic ACC with low FDG uptake on PET scan. Her circulating levels of androgens were high, and androgen-synthesis enzymes were detected in carcinoma cells. The patient also had hypocholesterolemia. However, glucose transporter 1 (GLUT1) was not detected in the tumor, which was considered to account for the low FDG uptake by the tumor. To the best of our knowledge, this is the first case of low FDG uptake by oncocytic ACC without GLUT1 expression. Additionally, since hypocholesterolemia was reported in 3 previous reports of androgen-producing tumors, a possible correlation between androgenicity in adrenal tumors and the development of hypocholesterolemia could be postulated; however, further investigations are needed for clarification. This case highlights important information regarding the diversity of ACC and its impact on hypocholesterolemia.

Report this publication

Statistics

Seen <100 times