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Oligopeptidase B, a missing enzyme in mammals and a potential drug target for trypanosomatid diseases.

Authors
  • Motta, Flávia Nader1
  • Azevedo, Clênia Dos Santos2
  • Neves, Beatriz Pereira3
  • Araújo, Carla Nunes de4
  • Grellier, Philippe5
  • Santana, Jaime Martins de3
  • Bastos, Izabela Marques Dourado6
  • 1 Pathogen-Host Interface Laboratory, Department of Cell Biology, University of Brasilia, Brasilia, Brazil; Faculdade de Ceilândia, Universidade de Brasília, Brasília, DF, Brazil. Electronic address: [email protected] , (Brazil)
  • 2 Pathogen-Host Interface Laboratory, Department of Cell Biology, University of Brasilia, Brasilia, Brazil; UMR7245 MCAM, Muséum National d'Histoire Naturelle, CNRS, CP54, 57 Rue Cuvier, Paris, France. , (Brazil)
  • 3 Pathogen-Host Interface Laboratory, Department of Cell Biology, University of Brasilia, Brasilia, Brazil. , (Brazil)
  • 4 Pathogen-Host Interface Laboratory, Department of Cell Biology, University of Brasilia, Brasilia, Brazil; Faculdade de Ceilândia, Universidade de Brasília, Brasília, DF, Brazil. , (Brazil)
  • 5 UMR7245 MCAM, Muséum National d'Histoire Naturelle, CNRS, CP54, 57 Rue Cuvier, Paris, France. , (France)
  • 6 Pathogen-Host Interface Laboratory, Department of Cell Biology, University of Brasilia, Brasilia, Brazil. Electronic address: [email protected] , (Brazil)
Type
Published Article
Journal
Biochimie
Publication Date
Dec 01, 2019
Volume
167
Pages
207–216
Identifiers
DOI: 10.1016/j.biochi.2019.10.006
PMID: 31628976
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Oligopeptidases B (OPB) belong to the S9 prolyl oligopeptidase family and are expressed in prokaryotes, some eukaryotes and in some higher plants. OPB is not found in any of the mammalian genomes available to date. Evidences indicate that OPB participates in the infections caused by trypanosomatids Trypanosoma cruzi, Leishmania spp. and Trypanosoma brucei spp and therefore it is considered an important virulence factor. Trypanosomatids from the genera Leishmania and Trypanosoma also present other OPB, named OPB2. A more accurate investigation of trypanosomatid OPB sequences brought attention to what could be a third OPB sequence (OPB3). This review aims to discuss biochemical, structural, phylogenetic and functional properties of OPB and its potential as target for the development of drugs against Chagas disease, leishmaniasis and African trypanosomiasis. Copyright © 2019 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

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