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Oligomerization of p53 is necessary to inhibit its transcriptional transactivation property at high protein concentration.

Authors
  • Kristjuhan, A
  • Jaks, V
  • Rimm, I
  • Tooming, T
  • Maimets, T
Type
Published Article
Journal
Oncogene
Publisher
Springer Nature
Publication Date
May 07, 1998
Volume
16
Issue
18
Pages
2413–2418
Identifiers
PMID: 9620560
Source
Medline
License
Unknown

Abstract

We have previously shown that transactivation by tumor suppressor protein p53 can be inhibited in vivo at elevated protein concentrations. In this study we characterize the structural requirements of this function. We show that oligomerization domain of p53 is involved in loss of transactivation at high protein concentrations: mutants not able to oligomerize are neither able to suppress transactivation, although these transactivating properties can be untouched.

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