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Oligoclonal gamma-globulin of cerebrospinal fluid in neurobrucellosis.

Authors
Type
Published Article
Journal
Acta neurologica Scandinavica
Publication Date
Volume
61
Issue
1
Pages
42–48
Identifiers
PMID: 6156562
Source
Medline
License
Unknown

Abstract

The clinical manifestations and laboratory findings of two cases of neurobrucellosis are described. The cerebrospinal fluid (CSF) protein electrophoresis showed increased gamma-globulins and decreased relative values of pre-albumin and albumin, associated to high values of total CSF protein. The evidence of oligoclonal morphology of CSF gamma-globulins suggests that part of them had an intrathecal origin, in addition to an increased crossing of the damaged blood-CSF barrier. Similar oligoclonal appearance of CSF gamma-globulins was observed in two additional cases of neurobrucellosis previously reported.

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