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Olfactory event-related potentials: a new approach for the evaluation of olfaction in nasopharyngeal carcinoma patients treated with chemo-radiotherapy.

Authors
  • Galletti, B1
  • Santoro, R1
  • Mannella, V K1
  • Caminiti, F2
  • Bonanno, L2
  • De Salvo, S2
  • Cammaroto, G1
  • Galletti, F1
  • 1 Department of Otorhinolaryngology,University of Messina,Messina,Italy. , (Italy)
  • 2 Department of Research,Istituto di Ricovero e Cura a Carattere Scientifico ('IRCCS') Centro Neurolesi 'Bonino Pulejo',Messina,Italy. , (Italy)
Type
Published Article
Journal
The Journal of Laryngology & Otology
Publisher
Cambridge University Press
Publication Date
May 01, 2016
Volume
130
Issue
5
Pages
453–461
Identifiers
DOI: 10.1017/S0022215116000761
PMID: 26931794
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Olfactory dysfunction is a possible side effect of chemo-radiotherapy performed in patients affected by nasopharyngeal carcinoma. Self-rating measurements and olfactory event-related potentials were used and compared in order to evaluate the impact of this treatment on the olfactory system. Nine patients underwent subjective evaluation of olfactory function (using visual analogue scales for olfactory symptoms and quality of life, and a six-item Hyposmia Rating Scale), and a quantitative and objective measurement (olfactory event-related potentials). Spearman's rank correlation analyses highlighted significant relationships between the clinical scales and olfactory event-related potentials. Inter-group analyses showed significant differences in the latency and in the amplitude of olfactory event-related potentials between patients and controls. Taking into account the small sample size and the lack of pre-treatment assessment, olfactory event-related potentials seemed to allow a more objective diagnosis of unilateral and bilateral olfactory loss. Moreover, olfactory event-related potentials and subjective scales results were concordant.

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