Offline impact of transcranial focused ultrasound on cortical activation in primates.

Lennart Verhagen; Cécile Gallea; Davide Folloni; Charlotte Constans; Daria Ea Jensen; Harry Ahnine; Léa Roumazeilles; Mathieu Santin; Bashir Ahmed; Stéphane Lehericy; Miriam C Klein-Flügge; Kristine Krug; Rogier B Mars; Matthew Fs Rushworth; Pierre Pouget; Jean-François Aubry; Jerome Sallet

doi:10.7554/eLife.40541

Publisher Website

Offline impact of transcranial focused ultrasound on cortical activation in primates.

Authors

Verhagen, Lennart^{1, 2}
Gallea, Cécile³
Folloni, Davide^{1, 2}
Constans, Charlotte⁴
Jensen, Daria Ea^{1, 2}
Ahnine, Harry³
Roumazeilles, Léa^{1, 2}
Santin, Mathieu³
Ahmed, Bashir⁵
Lehericy, Stéphane³
Klein-Flügge, Miriam C^{1, 2}
Krug, Kristine⁵
Mars, Rogier B^{2, 6}
Rushworth, Matthew Fs^{1, 2}
Pouget, Pierre⁷
Aubry, Jean-François⁸
Sallet, Jerome^{1, 2}

¹ Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom. , (United Kingdom)
² Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom. , (United Kingdom)
³ Institute du Cerveau et de la Moelle épinière (ICM), Centre for NeuroImaging Research (CENIR), Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Paris, France. , (France)
⁴ Physics for Medicine Paris, Inserm, ESPCI Paris, CNRS, PSL Research University, Université Paris Diderot, Sorbonne Paris Cité, Paris, France. , (France)
⁵ Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom. , (United Kingdom)
⁶ Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands. , (Netherlands)
⁷ Institute du Cerveau et de la Moelle épinière (ICM), UMRS 975 INSERM, CNRS 7225, UMPC, Paris, France. , (France)
⁸ Physics for Medicine Paris, Inserm, ESPCI Paris, CNRS, PSL Research University, Paris, France. , (France)

Type

Published Article

Journal

eLife

Publisher

"eLife Sciences Organisation, Ltd."

Publication Date

Feb 12, 2019

Volume

8

Identifiers

DOI: 10.7554/eLife.40541

PMID: 30747105

Source

Medline

Keywords

Language

English

License

Unknown

Abstract

To understand brain circuits it is necessary both to record and manipulate their activity. Transcranial ultrasound stimulation (TUS) is a promising non-invasive brain stimulation technique. To date, investigations report short-lived neuromodulatory effects, but to deliver on its full potential for research and therapy, ultrasound protocols are required that induce longer-lasting 'offline' changes. Here, we present a TUS protocol that modulates brain activation in macaques for more than one hour after 40 s of stimulation, while circumventing auditory confounds. Normally activity in brain areas reflects activity in interconnected regions but TUS caused stimulated areas to interact more selectively with the rest of the brain. In a within-subject design, we observe regionally specific TUS effects for two medial frontal brain regions - supplementary motor area and frontal polar cortex. Independently of these site-specific effects, TUS also induced signal changes in the meningeal compartment. TUS effects were temporary and not associated with microstructural changes. © 2019, Verhagen et al.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 02/18/2020 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/30747105

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