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Offline impact of transcranial focused ultrasound on cortical activation in primates.

Authors
  • Verhagen, Lennart1, 2
  • Gallea, Cécile3
  • Folloni, Davide1, 2
  • Constans, Charlotte4
  • Jensen, Daria Ea1, 2
  • Ahnine, Harry3
  • Roumazeilles, Léa1, 2
  • Santin, Mathieu3
  • Ahmed, Bashir5
  • Lehericy, Stéphane3
  • Klein-Flügge, Miriam C1, 2
  • Krug, Kristine5
  • Mars, Rogier B2, 6
  • Rushworth, Matthew Fs1, 2
  • Pouget, Pierre7
  • Aubry, Jean-François8
  • Sallet, Jerome1, 2
  • 1 Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom. , (United Kingdom)
  • 2 Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom. , (United Kingdom)
  • 3 Institute du Cerveau et de la Moelle épinière (ICM), Centre for NeuroImaging Research (CENIR), Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Paris, France. , (France)
  • 4 Physics for Medicine Paris, Inserm, ESPCI Paris, CNRS, PSL Research University, Université Paris Diderot, Sorbonne Paris Cité, Paris, France. , (France)
  • 5 Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom. , (United Kingdom)
  • 6 Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands. , (Netherlands)
  • 7 Institute du Cerveau et de la Moelle épinière (ICM), UMRS 975 INSERM, CNRS 7225, UMPC, Paris, France. , (France)
  • 8 Physics for Medicine Paris, Inserm, ESPCI Paris, CNRS, PSL Research University, Paris, France. , (France)
Type
Published Article
Journal
eLife
Publisher
"eLife Sciences Organisation, Ltd."
Publication Date
Feb 12, 2019
Volume
8
Identifiers
DOI: 10.7554/eLife.40541
PMID: 30747105
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To understand brain circuits it is necessary both to record and manipulate their activity. Transcranial ultrasound stimulation (TUS) is a promising non-invasive brain stimulation technique. To date, investigations report short-lived neuromodulatory effects, but to deliver on its full potential for research and therapy, ultrasound protocols are required that induce longer-lasting 'offline' changes. Here, we present a TUS protocol that modulates brain activation in macaques for more than one hour after 40 s of stimulation, while circumventing auditory confounds. Normally activity in brain areas reflects activity in interconnected regions but TUS caused stimulated areas to interact more selectively with the rest of the brain. In a within-subject design, we observe regionally specific TUS effects for two medial frontal brain regions - supplementary motor area and frontal polar cortex. Independently of these site-specific effects, TUS also induced signal changes in the meningeal compartment. TUS effects were temporary and not associated with microstructural changes. © 2019, Verhagen et al.

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