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Ocular motor and imaging abnormalities of midbrain dysfunction in osmotic demyelination syndrome.

Authors
  • Hawthorne, Kristen M
  • Compton, Christopher J
  • Vaphiades, Michael S
  • Roberson, Glenn H
  • Kline, Lanning B
Type
Published Article
Journal
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
Publication Date
Dec 01, 2009
Volume
29
Issue
4
Pages
296–299
Identifiers
DOI: 10.1097/WNO.0b013e3181c25390
PMID: 19952903
Source
Medline
License
Unknown

Abstract

After rapid correction of severe hyponatremia, a 36-year-old man developed osmotic demyelination syndrome (ODS), manifested neurologically by impaired cognition, extremity weakness, bilateral third cranial nerve palsies, and gaze-evoked upbeat and rotary nystagmus. Brain MRI showed restricted diffusion in the rostral midbrain and temporal and parietal lobes but not in the pons. Over several weeks, all neurologic and imaging deficits resolved. This is the first report to document ocular motor abnormalities associated with midbrain dysfunction in ODS.

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