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[Ocular melanomas : An update].

Authors
  • Kalirai, H1
  • Müller, P L2
  • Jaehne, D3
  • Coupland, S E4, 5
  • 1 Liverpool Ocular Oncology Research Group, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, Großbritannien.
  • 2 Universitäts-Augenklinik Bonn, Bonn, Deutschland.
  • 3 Institut für Gewebediagnostik Pathologie MVZ HELIOS Klinik Emil von Behring, Berlin, Deutschland.
  • 4 Liverpool Ocular Oncology Research Group, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, Großbritannien. [email protected]
  • 5 Institute of Translational Medicine, 6th Floor Duncan Building, University of Liverpool, Daulby Street, L69 3GA, Liverpool, Großbritannien. [email protected]
Type
Published Article
Journal
Der Pathologe
Publication Date
Nov 01, 2017
Volume
38
Issue
6
Pages
491–499
Identifiers
DOI: 10.1007/s00292-017-0389-3
PMID: 29038913
Source
Medline
Keywords
License
Unknown

Abstract

Melanoma is the most common type of primary cancer to affect the adult eye. Approximately 95% of ocular melanomas are intraocular and arise from the uvea (i. e. iris, ciliary body, and choroid), while the remaining 5% are located in the conjunctiva. Although both uveal and conjunctival melanomas are thought to derive from malignantly transformed melanocytes, uveal melanoma is clinically and biologically distinct from conjunctival melanoma, and indeed from its more common cutaneous counterpart. Intense efforts have been recently made to understand the molecular biology involved in the development of ocular melanomas, and in their progression. Molecular advances, particularly for uveal melanoma, have enhanced prognostication and the identification of rational therapeutic targets for disseminated disease. In this review, recent advances in the molecular characterisation of both uveal and conjunctival melanomas are discussed, and how these may be used to develop personalised therapeutic strategies.

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