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Obstructive sleep apnea, shift work and cardiometabolic risk.

Authors
  • Santos, Inês1
  • Rocha, Isabel2
  • Gozal, David3
  • Meira E Cruz, Miguel4
  • 1 Sleep Unit, Cardiovascular Center of University of Lisbon, Lisbon School of Medicine, Lisbon, Portugal. Electronic address: [email protected] , (Portugal)
  • 2 Cardiovascular Autonomic Function Lab, Cardiovascular Center of University of Lisbon, Lisbon School of Medicine, Lisbon, Portugal. Electronic address: [email protected] , (Portugal)
  • 3 Department of Child Health and Child Health Research Institute, University of Missouri School of Medicine, Columbia, MO, USA. Electronic address: [email protected]
  • 4 Sleep Unit, Cardiovascular Center of University of Lisbon, Lisbon School of Medicine, Lisbon, Portugal. Electronic address: [email protected] , (Portugal)
Type
Published Article
Journal
Sleep medicine
Publication Date
Oct 01, 2020
Volume
74
Pages
132–140
Identifiers
DOI: 10.1016/j.sleep.2020.05.013
PMID: 32858273
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Obstructive Sleep Apnea (OSA) is one of the most common sleep disorders, and invokes numerous negative health-related outcomes and physiopathological processes. Understanding the mechanisms by which OSA potentiates cardiometabolic risk of patients remains a current challenge. Sleep disruption is highly prevalent among shift workers and shift work (SW) is an important modulator of circadian rhythms, with health consequences intimately related to cardiometabolic health. Since the circadian timing system (CTS) interacts with the normal functioning of the ANS, CTS impact on OSA patients should be closely assessed. This review raises the question of whether SW-induced circadian misalignment potentiates the cardiometabolic risk of OSA patients, providing a novel perspective on the role of autonomic modulation as a key downstream mechanism linking cardiometabolic risk with both OSA and CTS misalignment. Copyright © 2020 Elsevier B.V. All rights reserved.

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