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Obstructive Sleep Apnea in Patients with Congenital Long QT Syndrome: Implications for Increased Risk of Sudden Cardiac Death.

Authors
  • Shamsuzzaman, Abu S1, 2, 3
  • Somers, Virend K3
  • Knilans, Timothy K2
  • Ackerman, Michael J3, 4
  • Wang, Yu5
  • Amin, Raouf S1, 2
  • 1 Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
  • 2 Department of Pediatrics, University of Cincinnati, Cincinnati, OH.
  • 3 Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN.
  • 4 Departments of Pediatrics and Molecular Pharmacology and Experimental Therapeutics; Division of Pediatric Cardiology; Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN.
  • 5 Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Type
Published Article
Journal
SLEEP
Publisher
Oxford University Press
Publication Date
Jul 01, 2015
Volume
38
Issue
7
Pages
1113–1119
Identifiers
DOI: 10.5665/sleep.4824
PMID: 26118557
Source
Medline
Keywords
License
Unknown

Abstract

The presence and severity of obstructive sleep apnea (OSA) in patients with congenital long QT syndrome (LQTS) is associated with increased QT prolongation corrected for heart rate, which is an important biomarker of sudden cardiac death (SCD). Treatment of OSA in LQTS patients may reduce QT prolongation, thus reducing the risk of LQT-triggered SCD.

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