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Obstetric complications and intelligence in patients on the schizophrenia-bipolar spectrum and healthy participants.

Authors
  • Wortinger, Laura Anne1, 2
  • Engen, Kristine1, 2
  • Barth, Claudia2
  • Lonning, Vera1, 2
  • Jørgensen, Kjetil Nordbø1, 2
  • Andreassen, Ole A2
  • Haukvik, Unn Kristin2
  • Vaskinn, Anja2
  • Ueland, Torill2, 3
  • Agartz, Ingrid1, 2, 4
  • 1 Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway. , (Norway)
  • 2 NORMENT, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway. , (Norway)
  • 3 Department of Psychology, University of Oslo, Oslo, Norway. , (Norway)
  • 4 Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institute, Stockholm, Sweden. , (Sweden)
Type
Published Article
Journal
Psychological Medicine
Publisher
Cambridge University Press
Publication Date
Aug 01, 2020
Volume
50
Issue
11
Pages
1914–1922
Identifiers
DOI: 10.1017/S0033291719002046
PMID: 31456537
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Whether severe obstetric complications (OCs), which harm neural function in offspring, contribute to impaired cognition found in psychiatric disorders is currently unknown. Here, we sought to evaluate how a history of severe OCs is associated with cognitive functioning, indicated by Intelligence Quotient (IQ). We evaluated the associations of a history of OCs and IQ in 622 healthy controls (HC) and 870 patients on the schizophrenia (SCZ) - bipolar disorder (BIP) spectrum from the ongoing Thematically Organized Psychosis study cohort, Oslo, Norway. Participants underwent assessments using the NART (premorbid IQ) and the WASI (current IQ). Information about OCs was obtained from the Medical Birth Registry of Norway. Multiple linear regression models were used for analysis. Severe OCs were equally common across groups. SCZ patients with OCs had lower performances on both premorbid and current IQ measures, compared to those without OCs. However, having experienced more than one co-occurring severe OC was associated with lower current IQ in all groups. Severe OCs were associated with lower IQ in the SCZ group and in the BIP and HC groups, but only if they had experienced more than one severe OC. Low IQ might be a neurodevelopmental marker for SCZ; wherein, severe OCs influence cognitive abilities and increase the risk of developing SCZ. Considering OCs as a variable of neurodevelopmental risk for severe mental illness may promote the development of neuroprotective interventions, improve outcome in vulnerable newborns and advance our ability to make clinical prognoses.

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