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Observations on the stability of foot and mouth disease vaccine antigens.

Authors
  • Anderson, E C
  • Doughty, W J
  • Muthiani, A
Type
Published Article
Journal
Vaccine
Publisher
Elsevier
Publication Date
Dec 01, 1983
Volume
1
Issue
1
Pages
26–30
Identifiers
PMID: 6099640
Source
Medline
License
Unknown

Abstract

The 146S particle of the foot and mouth disease virus which is used as a vaccine antigen was found to be relatively stable when stored for prolonged periods at 4 degrees C. However, stored antigens of virus strains of the SAT serotypes but not of a virus strain of the type O serotype became less thermostable at 37 degrees C following 4 degrees C storage. Vaccines returned from the field 10 months after they were made were shown to contain significant amounts of 146S antigen of the O, A, SAT 1 and SAT 2 serotypes. Vaccine containing antigens at least 6 months old was shown to stimulate an acceptable immune response.

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