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Observation of curative efficacy and prognosis following combination chemotherapy with celecoxib in the treatment of advanced colorectal cancer.

Authors
  • Jin, C-H
  • Wang, A-H
  • Chen, J-M
  • Li, R-X
  • Liu, X-M
  • Wang, G-P
  • Xing, L-Q
Type
Published Article
Journal
The Journal of international medical research
Publication Date
Jan 01, 2011
Volume
39
Issue
6
Pages
2129–2140
Identifiers
PMID: 22289528
Source
Medline
License
Unknown

Abstract

This study investigated the antitumour and chemosensitizing effects of celecoxib in the treatment of advanced colorectal cancer. A total of 90 patients were randomly divided into two groups: group CF was treated with a combination of celecoxib and the folinic acid-fluorouracil-oxaliplatin (FOLFOX4) regimen; and group F was treated with the FOLFOX4 regimen alone. Immunohisto chemical analysis of tumour tissues for cyclooxygenase-2 (COX-2) protein was performed. With regard to short-term efficacy, the response and disease control rates were significantly greater in group CF than group F. A log-rank test showed that the 3-year survival rate was significantly greater in group CF than group F. It was concluded that the addition of celecoxib to the FOLFOX4 regimen increased the short-term efficacy and the 3-year survival rate, and improved the quality of life of patients with advanced colorectal cancer. The antitumour and chemo sensitizing effects of celecoxib appeared to be independent of COX-2.

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