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Objective evaluation for treat to target in Crohn’s disease

Authors
  • Takenaka, Kento1, 1
  • Kitazume, Yoshio1
  • Fujii, Toshimitsu1
  • Tsuchiya, Kiichiro1
  • Watanabe, Mamoru1, 1
  • Ohtsuka, Kazuo2
  • 1 Tokyo Medical and Dental University,
  • 2 Tokyo Medical and Dental University Hospital,
Type
Published Article
Journal
Journal of Gastroenterology
Publisher
Springer Singapore
Publication Date
Mar 04, 2020
Volume
55
Issue
6
Pages
579–587
Identifiers
DOI: 10.1007/s00535-020-01678-8
PMID: 32130521
PMCID: PMC7242491
Source
PubMed Central
Keywords
License
Unknown

Abstract

Background Crohn’s disease (CD) is a chronic and destructive bowel disease; continued disease activity can lead to penetrating complications. With the recent advent of effective medications, the importance of using a treat-to-target approach to guide therapy is becoming important. Methods In this review, we reviewed the previous evidence for evaluating CD lesions. Results We describe ileocolonoscopy’s role in assessing disease activity, as well as recent progress in modalities, such as balloon-assisted endoscopy, capsule endoscopy, magnetic resonance enterography, computed tomography enterography, and ultrasonography. Advances in modalities have changed CD assessment, with small-bowel involvement becoming more important. Conclusions Proper optimization is necessary in clinical practice.

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