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Obesity and diabetes: lipids, 'nowhere to run to'.

Authors
  • Hill, Margaret J
  • Metcalfe, David
  • McTernan, Philip G
Type
Published Article
Journal
Clinical Science
Publisher
Portland Press
Publication Date
Jan 01, 2009
Volume
116
Issue
2
Pages
113–123
Identifiers
DOI: 10.1042/CS20080050
PMID: 19076064
Source
Medline
License
Unknown

Abstract

Although specific pathogenic entities contributing to diabetic risk, such as central adiposity, ectopic fat accumulation, hyperlipidaemia and inflammation, are well-characterized, the response of cellular systems to such insults are less well understood. This short review highlights the effect of increasing fat mass on ectopic fat accumulation, the role of triacylglycerols (triglycerides) in Type 2 diabetes mellitus and cardiovascular disease pathogenesis, and selected current therapeutic strategies used to ameliorate these risk factors.

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