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O6-methylguanine-DNA methyltransferase gene coding region polymorphisms and oral cancer risk.

Authors
  • Huang, Sung-Hsien1
  • Chang, Pei-Yang
  • Liu, Chung-Ji
  • Lin, Ming-Wei
  • Hsia, Kan-Tai
  • 1 Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei, Taiwan. , (Taiwan)
Type
Published Article
Journal
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Publication Date
Sep 01, 2010
Volume
39
Issue
8
Pages
645–650
Identifiers
DOI: 10.1111/j.1600-0714.2009.00880.x
PMID: 20412404
Source
Medline
License
Unknown

Abstract

The present study did not find statistically significant association between six common MGMT polymorphisms and oral cancer risk, however, both MGMT L53L and L84F polymorphisms in old patients with CT genotype have higher overall survival rates than patients with CC genotype. Because of limited power of the present study, further study may be warranted in ethnically different populations to explore outcomes of these polymorphisms in the oral cancer risk.

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