The clinical decision support system makes electronic health records (EHRs) structured, intelligent, and knowledgeable. The nursing decision support system (NDSS) is based on clinical nursing guidelines and nursing process to provide intelligent suggestions and reminders. The impact on nurses’ work is mainly in shortening the recording time, improving the quality of nursing diagnosis, reducing the incidence of nursing risk events, and so on. However, there is no authoritative standard for the NDSS at home and abroad. This review introduces development and challenges of EHRs and recommends the application of the NDSS in EHRs, namely the nursing assessment decision support system, the nursing diagnostic decision support system, and the nursing care planning decision support system (including nursing intervene), hoping to provide a new thought and method to structure impeccable EHRs.