Objective: To explore the operative nursing coordination method for the treatment of congenital atrial septal defect (ASD) by transcatheter closure of atrial septal defect via femoral vein. It provides useful experience for the treatment of congenital heart disease. Methods a total of 12 patients undergoing minimally invasive atrial septal defect closure via femoral vein from January 2017 to November 2017 in our department of cardiac surgery were selected as the subjects. All patients received transesophageal ultrasound guided ASD occlusion by femoral vein. The operation and nursing contents include preoperative care, the cooperation of the itinerant nurses, the coordination of the instrument nurses and the postoperative nursing. Results the operation of 12 patients in this group was successful. The diameter of the occluder was 17.1 + 4.5mm during the operation. The time of tracheal intubation was 2.4 + 0.7h, from the femoral vein to the sheath tube time was 38.7 + 9.4min, the occupancy of ICU was 12.5 + 2.6h after the operation. The average time of hospitalization was 4.5 + 1.8D. There were 2 cases of shunt 1mm immediately after operation. After 24h reexamination, the shunt disappeared, the heart murmur disappeared in the rest of the patients. No residual shunt and other complications occurred.