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Nurr1 transcriptionally regulates the expression of alpha-synuclein.

Authors
Type
Published Article
Journal
Neuroreport
0959-4965
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Volume
19
Issue
8
Pages
867–871
Identifiers
DOI: 10.1097/WNR.0b013e3282ffda48
PMID: 18463503
Source
Medline
License
Unknown

Abstract

Parkinson's disease is one of the most common neurodegenerative disorders and still remains incurable. The condition is linked to mutations and alterations in expression in several genes, in particular that encoding alpha-synuclein. Mutations in Nurr1 leading to a reduction in expression were also found to lead to Parkinson's disease. In view of the importance of gene regulation in Parkinson's disease, we examined the effect of changes in Nurr1 expression on alpha-synuclein expression. Nurr1 was shown to be involved in the regulation of alpha-synuclein, as decreased expression of Nurr1, which has been found in Parkinson's disease patients with Nurr1 mutations, was shown to transcriptionally increase alpha-synuclein expression.

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