Bismuth Eutectic (LBE) spallation target will be installed in the target test facility and bombarded by pulsed proton beams (250 kW, 400 MeV, 25 Hz, and 0.5 ms pulse duration). To realize the LBE spallation target, cavitation damage due to pressure changes in the liquid metal should be determined, preliminarily, because such damage is considered to be very critical, from the viewpoint of target safety and lifetime. In this study, cavitation damage due to pressure waves caused by pulsed proton beam injection and turbulent liquid metal flow, were studied, numerically, from the viewpoint of single cavitation bubble dynamics. Specifically, the threshold of cavitation and effects of flow speed fluctuation on cavitation bubble dynamics, in an orifice structure, were investigated in the present work. The results showed that the LBE spallation target did not undergo cavitation damage, under normal nominal operation conditions, mainly because of the long pulse duration of the pulsed proton beam and the low liquid metal flow velocity. Nevertheless, the possibility of cavitation damage in the orifice structure, under certain extreme transient LBE flow conditions, cannot be neglected.