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Numerical and functional deficiencies of natural killer T cells in systemic lupus erythematosus: their deficiency related to disease activity.

Authors
  • Cho, Young-Nan
  • Kee, Seung-Jung
  • Lee, Sung-Ji
  • Seo, Seong-Rye
  • Kim, Tae-Jong
  • Lee, Shin-Seok
  • Kim, Min-Soo
  • Lee, Won-Woo
  • Yoo, Dae-Hyun
  • Kim, Nacksung
  • Park, Yong-Wook
Type
Published Article
Journal
Rheumatology (Oxford, England)
Publication Date
Jun 01, 2011
Volume
50
Issue
6
Pages
1054–1063
Identifiers
DOI: 10.1093/rheumatology/keq457
PMID: 21278064
Source
Medline
License
Unknown

Abstract

Our data show that NKT cell levels and functions are defective in SLE patients. Furthermore, these deficiencies were found to reflect disease activity. It would appear that these NKT cell abnormalities could contribute to immune system dysregulation in SLE.

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