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The number of T cell allo-epitopes associates with CD4+ and CD8+ T-cell infiltration in pediatric cutaneous GVHD.

Authors
  • Thus, Kirsten A
  • van Halteren, Astrid G S
  • de Hond, Titus A P
  • van Dijk, Marijke R
  • Kloos, Robin Q H
  • Lankester, Arjan C
  • Bierings, Marc B
  • Spierings, Eric
Type
Published Article
Journal
Cellular Immunology
Publisher
Elsevier
Publication Date
Jun 01, 2015
Volume
295
Issue
2
Pages
112–117
Identifiers
DOI: 10.1016/j.cellimm.2015.03.001
PMID: 25880102
Source
Medline
Keywords
License
Unknown

Abstract

Risk factors for graft-versus-host disease (GVHD) following allogeneic hematopoietic stem-cell transplantation (HCST) include: HLA mismatches, sex-mismatch, and stem-cell source. We retrospectively analyzed if HLA- and sex-mismatching quantitatively affects the composition of GVHD-induced T-cell infiltrates. We quantified absolute numbers of CD4+ and CD8+ T cells present in tissue sections from skin biopsies of 23 pediatric HSCT-recipients with GVHD. HSCT with a sex-mismatched unrelated donor was associated with an increased number of CD4+ T cells when compared to a sex-matched unrelated donor (p=0.01). The absolute numbers of skin-infiltrating T cells were increased in patients expressing T-cell epitopes derived from the recipient's mismatched HLA, so called predicted indirectly recognizable HLA epitopes (PIRCHE). The combined expression of PIRCHE with a sex-mismatch resulted in the highest number of skin-infiltrating T cells. Our results indicate that an increased number of recipient-specific T-cell epitopes is associated with accumulation of CD4+ and CD8+ T cells in the skin.

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