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A nucleotide substitution model with nearest-neighbour interactions.

Authors
  • Lunter, Gerton
  • Hein, Jotun
Type
Published Article
Journal
Bioinformatics (Oxford, England)
Publication Date
Aug 04, 2004
Volume
20 Suppl 1
Identifiers
PMID: 15262802
Source
Medline
License
Unknown

Abstract

We applied the model upon aligned human-mouse non-coding data. Clear neighbour dependencies were observed, including 17-18-fold increased CpG to TpG/CpA rates compared with other substitutions. Root inference positioned the root halfway the mouse and human tips, suggesting an approximately clock-like behaviour of the irreversible part of the substitution process.

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