Affordable Access

deepdyve-link
Publisher Website

Nucleosides 5(15): synthesis of novel 1,2,4-triazolo[3,4-c]-1,2,4-triazole nucleosides.

Authors
  • Mosselhi, M A N
  • Neidlein, R
Type
Published Article
Journal
Nucleosides, nucleotides & nucleic acids
Publication Date
Nov 01, 2009
Volume
28
Issue
11
Pages
1095–1103
Identifiers
DOI: 10.1080/15257770903368377
PMID: 20183576
Source
Medline
License
Unknown

Abstract

Ribosylation of 3-methylthio-5-phenyl-1,2,4-triazole (1) with ribose derivative 2 gave the protected 1,2,4-triazole-nucleoside 3, which reacted with hydrazine hydrate to afford the 3-hydrazino-1,2,4-triazole derivative 5. Reaction of 5 with aromatic aldehydes yielded the corresponding hydrazones 6, which cyclized under bromination in acetic acid to give 8. Debenzoylation of 8 afforded novel 1,2,4-triazolo[3,4-c]-1,2,4-triazole nucleosides 9.

Report this publication

Statistics

Seen <100 times