Affordable Access

Nucleolus-associated J chains in myeloma cells.

Authors
  • Kanoh, T
  • Ohnaka, T
  • Takamatsu, T
  • Ohno, T
  • Uchino, H
  • Horiguchi, Y
Type
Published Article
Journal
Scandinavian journal of haematology
Publication Date
Nov 01, 1986
Volume
37
Issue
5
Pages
443–447
Identifiers
PMID: 3101168
Source
Medline
License
Unknown

Abstract

Bone marrow aspirates from 10 patients with multiple myeloma (6 IgG myeloma, 3 IgA myeloma, 1 Bence Jones myeloma) were examined for nucleolus-associated localization of J chains. On light microscopy using the PAP method, almost all or a significant number of myeloma cells exhibited intranuclear spots stained with anti-J chains in 3 (IgG myeloma) out of the 8 cases positive for cytoplasmic J chains. In contrast, the nucleus of myeloma cells examined was constantly negative for anti-heavy and -light chains. Immunoelectron microscopically, J chain was identified as dicrete round electron-dense precipitates, corresponding to the whole nucleolus, and as sparsely distributed, small electron-dense deposits in the nucleus. In addition, some connections were found between nuclear and nucleolar electron-dense precipitates. Several possible explanations have been proposed to account for this localization of J chains.

Report this publication

Statistics

Seen <100 times