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Nucleic acid synthesis in cytoplasm of Yaba monkey tumor virus-infected cells.

Authors
  • Rouhandeh, H
  • Rouhandeh, M L
Type
Published Article
Journal
Journal of virology
Publication Date
Dec 01, 1973
Volume
12
Issue
6
Pages
1407–1413
Identifiers
PMID: 4357513
Source
Medline
License
Unknown

Abstract

Yaba tumor virus progeny appeared in cynomolgus monkey kidney cells at 24 h postinfection and reached a plateau at 72 h in the first cycle of replication. Viral DNA synthesis was first detected at about 3 h and reached a peak in 18 h. Maximum coating of viral DNA in infected cells occurred at 4 days postinfection. Rapidly labeled RNA was synthesized in the cytoplasm of virus-infected cells. At 6 h postinfection 7 to 10S RNA was present; this species was present in greater amount at 12 h; at 24 h a truncated peak indicated the presence of 14 to 15S as well as 7 to 10S RNA. Hybridization data indicated that the largest peak of messenger RNA synthesis occurred at 11 to 13 h postinfection and a second, slightly smaller, peak occurred at 21 to 23 h.

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