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Nuclear localization of phosphorylated c-Myc protein in human tumor cells.

Authors
Type
Published Article
Journal
European journal of histochemistry : EJH
Publication Date
Volume
46
Issue
4
Pages
377–380
Identifiers
PMID: 12597623
Source
Medline

Abstract

Using immunocytochemical techniques at light and electron microscopy, we analysed the distribution of phosphorylated c-Myc in actively proliferating human HeLa cells. The distribution pattern of c-Myc was also compared with those of other ribonucleoprotein (RNP)-containing components (PANA, hnRNP-core proteins, fibrillarin) or RNP-associated nuclear proteins (SC-35 splicing factor). Our results provide the first evidence that phosphorylated c-Myc accumulates in the nucleus of tumor cells, where it colocalizes with fibrillarin, both in the nucleolus and in extranucleolar structures.

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