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Nuclear lamins.

Authors
  • Dechat, Thomas
  • Adam, Stephen A
  • Taimen, Pekka
  • Shimi, Takeshi
  • Goldman, Robert D
Type
Published Article
Journal
Cold Spring Harbor Perspectives in Biology
Publisher
Cold Spring Harbor Laboratory
Publication Date
Nov 01, 2010
Volume
2
Issue
11
Identifiers
DOI: 10.1101/cshperspect.a000547
PMID: 20826548
Source
Medline
License
Unknown

Abstract

The nuclear lamins are type V intermediate filament proteins that are critically important for the structural properties of the nucleus. In addition, they are involved in the regulation of numerous nuclear processes, including DNA replication, transcription and chromatin organization. The developmentally regulated expression of lamins suggests that they are involved in cellular differentiation. Their assembly dynamic properties throughout the cell cycle, particularly in mitosis, are influenced by posttranslational modifications. Lamins may regulate nuclear functions by direct interactions with chromatin and determining the spatial organization of chromosomes within the nuclear space. They may also regulate chromatin functions by interacting with factors that epigenetically modify the chromatin or directly regulate replication or transcription.

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