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The nuclear import receptor Kpnβ1 and its potential as an anticancer therapeutic target.

Authors
  • van der Watt, Pauline J
  • Stowell, Catherine L
  • Leaner, Virna D
Type
Published Article
Journal
Critical reviews in eukaryotic gene expression
Publication Date
Jan 01, 2013
Volume
23
Issue
1
Pages
1–10
Identifiers
PMID: 23557333
Source
Medline
License
Unknown

Abstract

Many proteins require transport across the nuclear envelope, the physical barrier separating the nucleus from the cytoplasm. Karyopherin β (Kpnβ1) proteins are the major nuclear receptor proteins in the cell that cargo proteins across the nuclear envelope, allowing them to enter and exit the cell nucleus. Karyopherin β1, a major nuclear import receptor, plays an integral role in importing transcription factors, cell signaling proteins, cell cycle proteins, and so forth, into the nucleus, thus playing a crucial role in maintaining normal cell homeostasis. However, cancer cells appear to differentially regulate the expression of the Karyopherin β proteins, presumably in order to maintain increased nuclear transport rates, thus implicating this protein family as a target for cancer therapy. The role of Kpnβ1 in cancer is only now being elucidated, and recent work points to its potential usefulness as an anti-cancer target.

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