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Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice.

Authors
  • Li, Liang
  • Chen, Lei
  • Hu, Liang
  • Liu, Yuan
  • Sun, Han-Yong
  • Tang, Jing
  • Hou, Yu-Jie
  • Chang, Yan-Xin
  • Tu, Qian-Qian
  • Feng, Gen-Sheng
  • Shen, Feng
  • Wu, Meng-Chao
  • Wang, Hong-Yang
Type
Published Article
Journal
Hepatology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Nov 01, 2011
Volume
54
Issue
5
Pages
1620–1630
Identifiers
DOI: 10.1002/hep.24552
PMID: 21809356
Source
Medline
License
Unknown

Abstract

Our study supports the notion that TLR4/MyD88 signaling in liver parenchymal cells plays a pivotal role during the early progression of HFD-induced NAFLD, in which free HMGB1 served as a positive component mediating TLR4 activation.

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