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Nuclear envelope invaginations and cancer.

Authors
  • Malhas, Ashraf N
  • Vaux, David J
Type
Published Article
Journal
Advances in experimental medicine and biology
Publication Date
Jan 01, 2014
Volume
773
Pages
523–535
Identifiers
DOI: 10.1007/978-1-4899-8032-8_24
PMID: 24563364
Source
Medline
License
Unknown

Abstract

The nuclear envelope (NE) surrounds the nucleus and separates it from the cytoplasm. The NE is not a passive structural component, but rather contributes to various cellular processes such as genome organization, transcription, signaling, and stress responses. Although the NE is mostly a smooth surface, it also forms invaginations that can reach deep into the nucleoplasm and may even traverse the nucleus completely. Cancer cells are generally characterized by irregularities and invaginations of the NE that are of diagnostic and prognostic significance. In the current chapter, we describe the link between nuclear invaginations and irregularities with cancer and explore possible mechanistic roles they might have in tumorigenesis.

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