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The N-terminal pro brain natriuretic peptide is the best predictor of mortality during hospitalization in patients with low risk of sepsis-related organ failure.

Authors
  • García Villalba, Eva1
  • Bernal Morell, Enrique2
  • Egea, Mari Paz1
  • Marín, Irene1
  • Alcaraz Garcia, Antonia1
  • Muñoz, Angeles1
  • Vera, MariCarmen1
  • Valero, Salvador1
  • Martinez, Monica1
  • Callejo Hurtado, Victoria1
  • Gomez Verdu, Jose Miguel1
  • Santo, Angela1
  • Cano Sanchez, Alfredo3
  • 1 Sección de Enfermedades Infecciosas, Hospital Reina Sofía, Murcia, España.
  • 2 Universidad Católica San Antonio. Murcia, España. Electronic address: [email protected]
  • 3 Universidad de Murcia, Murcia, España.
Type
Published Article
Journal
Medicina Clínica
Publisher
Elsevier
Publication Date
Sep 08, 2017
Volume
149
Issue
5
Pages
189–195
Identifiers
DOI: 10.1016/j.medcli.2017.02.036
PMID: 28473224
Source
Medline
Keywords
License
Unknown

Abstract

A total of 174 patients were analyzed. Seventeen (9.8%) patients died during hospitalization. The AUC of NT-proBNP was 0.793 (95% CI 0.686-0.9; P<.0005) compared to AUC of CRP (0.728; 95% CI 0.617-0.839; P=.004) and AUC of PCT (0.684; 95% CI 0.557-0.811; P=.019). Factors independently associated with in-hospital mortality were NT-proBNP>1,330pg/ml (OR=23.23; 95% CI 2.92-182.25; P=.003) and to have predisposing factors (OR=3.05; 95% CI 1.3-9.3; P=.044) CONCLUSIONS: In patients with low mortality risk according to SOFA score, NT-proBNP obtained in the first 72h after admission prove to be a powerful predictor of mortality. Their implementations in clinical practice would improve the predictive ability of clinical severity scores.

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