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The N-space Episenome unifies cellular information space-time within cognition-based evolution.

Authors
  • Miller, William B Jr1
  • Torday, John S2
  • Baluška, František3
  • 1 Paradise Valley, AZ, USA. Electronic address: [email protected]
  • 2 Department of Pediatrics, Harbor-UCLA Medical Center, USA. Electronic address: [email protected]
  • 3 IZMB, University of Bonn, Kirschellee 1, 53115, Bonn, Germany. Electronic address: [email protected] , (Germany)
Type
Published Article
Journal
Progress in biophysics and molecular biology
Publication Date
Jan 01, 2020
Volume
150
Pages
112–139
Identifiers
DOI: 10.1016/j.pbiomolbio.2019.08.006
PMID: 31415772
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Self-referential cellular homeostasis is maintained by the measured assessment of both internal status and external conditions based within an integrated cellular information field. This cellular field attachment to biologic information space-time coordinates environmental inputs by connecting the cellular senome, as the sum of the sensory experiences of the cell, with its genome and epigenome. In multicellular organisms, individual cellular information fields aggregate into a collective information architectural matrix, termed a N-space Episenome, that enables mutualized organism-wide information management. It is hypothesized that biological organization represents a dual heritable system constituted by both its biological materiality and a conjoining N-space Episenome. It is further proposed that morphogenesis derives from reciprocations between these inter-related facets to yield coordinated multicellular growth and development. The N-space Episenome is conceived as a whole cell informational projection that is heritable, transferable via cell division and essential for the synchronous integration of the diverse self-referential cells that constitute holobionts. Copyright © 2019 Elsevier Ltd. All rights reserved.

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