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NR4As apply brakes on the B cell response

Authors
  • Hill, Louisa1
  • Schwickert, Tanja A.1
  • 1 Vienna Biocenter (VBC), Campus-Vienna-Biocenter 1, Vienna, Austria , Vienna (Austria)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Aug 31, 2020
Volume
21
Issue
10
Pages
1137–1139
Identifiers
DOI: 10.1038/s41590-020-0775-5
Source
Springer Nature
License
Yellow

Abstract

To trigger an adequate humoral immune response while ensuring self-tolerance, B cell activation is tightly controlled. A new study indicates that an NR4A-enforced built-in brake fine-tunes the early phase of transcriptional reprogramming induced by BCR stimulation.

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