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A novel zoonotic genotype related to Echinococcus granulosus sensu stricto from southern Ethiopia.

Authors
  • Wassermann, Marion1
  • Woldeyes, Daniel2
  • Gerbi, Banchwosen Mechal3
  • Ebi, Dennis4
  • Zeyhle, Eberhard5
  • Mackenstedt, Ute4
  • Petros, Beyene6
  • Tilahun, Getachew7
  • Kern, Peter8
  • Romig, Thomas4
  • 1 Department of Parasitology, University of Hohenheim, Stuttgart, Germany. Electronic address: [email protected] , (Germany)
  • 2 Department of Biology, Arba Minch University, Arba Minch, Ethiopia; Department of Microbial, Cellular and Molecular Biology, Addis Ababa University, Addis Ababa, Ethiopia. , (Ethiopia)
  • 3 Turmi Health Center, Hamer District, South Omo Zone, Ethiopia. , (Ethiopia)
  • 4 Department of Parasitology, University of Hohenheim, Stuttgart, Germany. , (Germany)
  • 5 Meru University of Science and Technology, Meru, Kenya. , (Kenya)
  • 6 Department of Microbial, Cellular and Molecular Biology, Addis Ababa University, Addis Ababa, Ethiopia. , (Ethiopia)
  • 7 Aklilu Lema Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia. , (Ethiopia)
  • 8 Comprehensive Infectious Diseases Center, University Hospitals, Ulm, Germany. , (Germany)
Type
Published Article
Journal
International journal for parasitology
Publication Date
Sep 01, 2016
Volume
46
Issue
10
Pages
663–668
Identifiers
DOI: 10.1016/j.ijpara.2016.04.005
PMID: 27181929
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Complete mitochondrial and two nuclear gene sequences of a novel genotype (GOmo) related to Echinococcus granulosus sensu stricto are described from a metacestode isolate retrieved from a human patient in southwestern Ethiopia. Phylogenetically, the genotype is positioned within the E. granulosus sensu stricto/Echinococcus felidis cluster, but cannot easily be allocated to either species. Based on different mitochondrial DNA markers, it is closest to the haplotype cluster that currently defines the species E. granulosus sensu stricto (which includes variants showing the widely cited G1, G2 and G3 sequences), but is clearly not part of this cluster. Pairwise distances between GOmo and E. granulosus sensu stricto are in the range of those between the most distant members of the Echinococcus canadensis complex (G6-10) that were recently proposed as separate species. At this stage, we prefer to list GOmo informally as a genotype rather than giving it any taxonomic rank because our knowledge rests on a single isolate from a dead-end host (human), and its lifecycle is unknown. According to data on molecularly characterised Echinococcus isolates from this region, GOmo has never been found in the usual livestock species that carry cystic echinococcosis and the possibility of a wildlife source of this newly recognised zoonotic agent cannot be excluded. The discovery of GOmo adds complexity to the already diverse array of cystic echinococcosis agents in sub-Saharan Africa and challenges hypotheses on the biogeographical origin of the E. granulosus sensu stricto clade. Copyright © 2016 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.

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