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A novel view on stem cell development: analysing the shape of cellular genealogies.

Authors
  • Glauche, I
  • Lorenz, R
  • Hasenclever, D
  • Roeder, I
Type
Published Article
Journal
Cell Proliferation
Publisher
Wiley (Blackwell Publishing)
Publication Date
Apr 01, 2009
Volume
42
Issue
2
Pages
248–263
Identifiers
DOI: 10.1111/j.1365-2184.2009.00586.x
PMID: 19254328
Source
Medline
License
Unknown

Abstract

Based on statistical analysis of cellular genealogies, we conclude that effects of external variables, such as growth conditions, are imprinted in their topology. Moreover, we demonstrate that it is essential to analyse timing of cell fate-specific changes and of occurrence of cell death events in the divisional context in order to understand the mechanisms of lineage commitment.

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