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Novel vancomycin resistance gene cluster in Enterococcus faecium ST1486, Belgium, June 2021

Authors
  • Xavier, Basil Britto1, 2
  • Coppens, Jasmine3
  • De Koster, Sien1, 2
  • Rajakani, Sahaya Glingston1, 2
  • Van Goethem, Sam3
  • Mzougui, Samy4
  • Anantharajah, Ahalieyah4
  • Lammens, Christine1, 2
  • Loens, Katherine3, 5
  • Glupczynski, Youri1, 2
  • Goossens, Herman1, 2, 3, 5
  • Matheeussen, Veerle3, 5
  • 1 Laboratory of Medical Microbiology, Universiteit Antwerpen, Wilrijk, Belgium
  • 2 Vaccine and Infectious Disease Institute, Universiteit Antwerpen, Wilrijk, Belgium
  • 3 Laboratory of Clinical Microbiology, Antwerp University Hospital, Edegem, Belgium
  • 4 Laboratory of Clinical Microbiology, Cliniques Universitaires Saint-Luc-UCLouvain, Brussels, Belgium
  • 5 Belgian National Reference Centre for Enterococci, Antwerp University Hospital, Edegem, Belgium
Type
Published Article
Journal
Eurosurveillance
Publisher
European Centre for Disease Control and Prevention (ECDC)
Publication Date
Sep 09, 2021
Volume
26
Issue
36
Identifiers
DOI: 10.2807/1560-7917.ES.2021.26.36.2100767
PMID: 34505571
PMCID: PMC8431993
Source
PubMed Central
Keywords
Disciplines
  • Rapid Communication
License
Unknown

Abstract

We identified a novel van gene cluster in a clinical Enterococcus faecium isolate with vancomycin minimum inhibitory concentration (MIC) of 4 µg/mL. The ligase gene, vanP , was part of a van operon cluster of 4,589 bp on a putative novel integrative conjugative element located in a ca 98 kb genomic region presumed to be acquired by horizontal gene transfer from Clostridium scidens and Roseburia sp. 499. Screening for van genes in E. faecium strains with borderline susceptibility to vancomycin is important.

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