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Novel therapeutic strategies via the apoptosis pathways to resolve chronic eosinophilic inflammation.

Authors
Type
Published Article
Journal
Cell Death and Differentiation
1350-9047
Publisher
Nature Publishing Group
Publication Date
Volume
3
Issue
4
Pages
349–356
Identifiers
PMID: 17180105
Source
Medline

Abstract

Physiologic cell death is a necessary process to maintain correct cell numbers. Alterations in this process may contribute to the pathogenesis of a number of human diseases. During the past few years, evidence has been adduced indicating that eosinophilic disorders are associated with a defect in eosinophil apoptosis. Here we review our recent progress in understanding the processes regulating eosinophil apoptosis, and the implications of these results for novel therapeutic possibilities.

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