A novel tetracycline from Actinomadura brunnea. Fermentation, isolation and structure elucidation.
- Published Article
The Journal of antibiotics
- Publication Date
Oct 01, 1987
A novel tetracycline antibiotic, Sch 33256, was isolated from a culture broth of a new species of Actinomadura. The antibiotic was isolated by solvent extraction, Sephadex G-25 column chromatography and crystallization. The structure was determined by comparison of the spectra with that of chlortetracycline. Spectroscopic analysis of the compound yielded 2'-N-methyl-8-methoxychlortetracycline as the proposed structure.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/3680005