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A novel tetracycline from Actinomadura brunnea. Fermentation, isolation and structure elucidation.

Authors
  • Patel, M
  • Gullo, V P
  • Hegde, V R
  • Horan, A C
  • Gentile, F
  • Marquez, J A
  • Miller, G H
  • Puar, M S
  • Waitz, J A
Type
Published Article
Journal
The Journal of antibiotics
Publication Date
Oct 01, 1987
Volume
40
Issue
10
Pages
1408–1413
Identifiers
PMID: 3680005
Source
Medline
License
Unknown

Abstract

A novel tetracycline antibiotic, Sch 33256, was isolated from a culture broth of a new species of Actinomadura. The antibiotic was isolated by solvent extraction, Sephadex G-25 column chromatography and crystallization. The structure was determined by comparison of the spectra with that of chlortetracycline. Spectroscopic analysis of the compound yielded 2'-N-methyl-8-methoxychlortetracycline as the proposed structure.

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