Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Novel targets for inflammatory bowel disease therapeutics.

Authors
  • Löwenberg, Mark
  • D'Haens, Geert
Type
Published Article
Journal
Current gastroenterology reports
Publication Date
Feb 01, 2013
Volume
15
Issue
2
Pages
311–311
Identifiers
DOI: 10.1007/s11894-012-0311-3
PMID: 23314806
Source
Medline
License
Unknown

Abstract

In recent years, many new agents have been evaluated for the treatment of inflammatory bowel disease. In this paper, we critically review recently published literature about these novel therapies, which have been the result of extensive research identifying molecular targets. Of the various biologicals and small molecules that have recently been tested in clinical trials, several demonstrated clinical efficacy with a tolerable safety profile. We discuss a number of them with specific focus on vedolizumab, a monoclonal antibody directed against the alpha4beta7 integrin on lymphocytes, ustekinumab, a monoclonal antibody against the p40 subunit of interleukin-12 and interleukin-23, and tofacitinib, a small molecule targeting Janus-activated kinase. Most likely, these three agents will find their way to the market and offer significant therapeutic alternatives for the management of Crohn's disease and/or ulcerative colitis.

Report this publication

Statistics

Seen <100 times