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Novel T7 Phage Display Library Detects Classifiers for Active Mycobacterium Tuberculosis Infection

Authors
  • Talwar, Harvinder
  • Hanoudi, Samer Najeeb
  • Draghici, Sorin
  • Samavati, Lobelia
Publication Date
Jul 19, 2018
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

0.01. Among those clones, we selected the top ten most significant clones and validated them on independent test set. The area under receiver operating characteristics (ROC) for the top 10 significant clones was 1 with a sensitivity of 1 and a specificity of 1. Sequence analyses of informative phage inserts recognized as antigens by active TB sera may identify immunogenic antigens that could be used to develop therapeutic or prophylactic vaccines, as well as identify molecular targets for therapy.

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