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Novel syntheses of tetrahydrobenzodiazepines and dihydropyrazines via isocyanide-based multicomponent reactions of diamines.

Authors
Type
Published Article
Journal
Journal of Combinatorial Chemistry
1520-4774
Publisher
American Chemical Society
Publication Date
Volume
12
Issue
1
Pages
186–190
Identifiers
DOI: 10.1021/cc900125a
PMID: 19928912
Source
Medline

Abstract

In this work, two novel isocyanide-based multicomponent reactions of 1,2-diamine compounds with diketene have been developed as efficient strategies for the synthesis of 2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-2-carboxamides with regiochemical control and 1,6-dihydropyrazine-2,3-dicarbonitriles in good to excellent yields at ambient temperature.

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