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Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents.

Authors
  • Gwaltney, S L 2nd
  • Imade, H M
  • Barr, K J
  • Li, Q
  • Gehrke, L
  • Credo, R B
  • Warner, R B
  • Lee, J Y
  • Kovar, P
  • Wang, J
  • Nukkala, M A
  • Zielinski, N A
  • Frost, D
  • Ng, S C
  • Sham, H L
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Apr 09, 2001
Volume
11
Issue
7
Pages
871–874
Identifiers
PMID: 11294380
Source
Medline
License
Unknown

Abstract

Sulfonate analogues of combretastatin A-4 have been prepared. These compounds compete with colchicine and combretastatin A-4 for the colchicine binding site on tubulin and are potent inhibitors of tubulin polymerization and cell proliferation. Importantly, these compounds also inhibit the proliferation of P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.

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