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A novel respiratory model of infection with monkeypox virus in cynomolgus macaques.

Authors
  • Goff, Arthur J
  • Chapman, Jennifer
  • Foster, Chad
  • Wlazlowski, Carly
  • Shamblin, Joshua
  • Lin, Kenny
  • Kreiselmeier, Norman
  • Mucker, Eric
  • Paragas, Jason
  • Lawler, James
  • Hensley, Lisa
Type
Published Article
Journal
Journal of Virology
Publisher
American Society for Microbiology
Publication Date
May 01, 2011
Volume
85
Issue
10
Pages
4898–4909
Identifiers
DOI: 10.1128/JVI.02525-10
PMID: 21389129
Source
Medline
License
Unknown

Abstract

Variola, the causative agent of smallpox, and the related monkeypox virus are both select agents that, if purposefully released, would cause public panic and social disruption. For this reason research continues in the areas of animal model and therapeutic development. Orthopoxviruses show a widely varying degree of host specificity, making development of accurate animal models difficult. In this paper, we demonstrate a novel respiratory infection technique that resulted in "classic" orthopox disease in nonhuman primates and takes the field of research one step closer to a better animal model.

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