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A novel recognition site for somatostatin-14 on the GABA(A) receptor complex.

Authors
  • Vincens, M
  • Mauvais-Jarvis, F
  • Behar, S
Type
Published Article
Journal
European Journal of Pharmacology
Publisher
Elsevier
Publication Date
Feb 26, 1998
Volume
344
Issue
1
Identifiers
PMID: 9570456
Source
Medline
License
Unknown

Abstract

Functional interactions between gamma-aminobutyric acid (GABA) and somatostatin are suggested by the presence of synaptic contacts between GABA and somatostatin neurons, colocalisation of GABA and somatostatin and reciprocal modulation of somatostatin and GABA release. Nevertheless, a direct interaction of somatostatin with the GABA(A) receptor complex has not yet been investigated. A quantitative autoradiographic technique was used to determine the ability of somatostatin to interact with the [35S]t-butylbicyclophosphothionate [35S]TBPS binding sites of the GABA(A) receptor complex: somatostatin inhibited [35S]TBPS binding with IC50 values in the micromolar range in all brain regions studied. These results demonstrate for the first time a direct interaction between somatostatin and the GABA(A) receptor complex.

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