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Novel rechargeable nano-CaF2 orthodontic cement with high levels of long-term fluoride release.

Authors
  • Yi, Jianru1
  • Weir, Michael D2
  • Melo, Mary A S3
  • Li, Tina2
  • Lynch, Christopher D4
  • Oates, Thomas W2
  • Dai, Quan5
  • Zhao, Zhihe6
  • Xu, Hockin H K7
  • 1 State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontic and Pediatric dentistry, West China Hospital of Stomatology, Sichuan University, China; Department of Advanced Oral Sciences and Therapeutics, School of Dentistry, University of Maryland, Baltimore, MD 21021, USA. , (China)
  • 2 Department of Advanced Oral Sciences and Therapeutics, School of Dentistry, University of Maryland, Baltimore, MD 21021, USA.
  • 3 Division of Operative Dentistry, Department of General Dentistry, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
  • 4 Restorative Dentistry, University Dental School and Hospital, University College Cork, Wilton, Cork, Ireland. , (Ireland)
  • 5 Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China. Electronic address: [email protected] , (China)
  • 6 State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontic and Pediatric dentistry, West China Hospital of Stomatology, Sichuan University, China. Electronic address: [email protected] , (China)
  • 7 Department of Advanced Oral Sciences and Therapeutics, School of Dentistry, University of Maryland, Baltimore, MD 21021, USA; Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA; Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. Electronic address: [email protected]
Type
Published Article
Journal
Journal of dentistry
Publication Date
Nov 01, 2019
Volume
90
Pages
103214–103214
Identifiers
DOI: 10.1016/j.jdent.2019.103214
PMID: 31629031
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Fluoride-containing orthodontic cements are used to combat white spot lesions (WSLs) in enamel. However, the fluoride (F) ion releases from these cements are relatively low and short-term. The objectives of this study were to develop a novel rechargeable orthodontic cement with nanoparticles of calcium fluoride (nCaF2) to provide long-term and high levels of F release, and to investigate F recharge and physical and cytotoxic properties. The nCaF2 with a mean particle size of 58 nm were synthesized using a spray-drying method. Pyromellitic glycerol dimethacrylate (PMGDM), ethoxylated bisphenol A dimethacrylate (EBPADMA), 2-hydroxyethyl methacrylate (HEMA) and bisphenol A glycidyl dimethacrylate (BisGMA) were used to prepare the cements (denoted PE and PEHB resins). A resin-modified glass ionomer (RMGI) served as control. Enamel shear bond strength (SBS), cytotoxicity, and F ion recharge and re-release were evaluated. nCaF2 cements had good SBS and excellent biocompatibility that were comparable to RMGI (p > 0.1). After a recharge for 1 min, the F re-release from PEHB + 30%nCaF2 cement was 80% higher than RMGI (p < 0.05). Increasing nCaF2 content from 20% to 30% greatly increased the F ion re-release (p < 0.05). The F ion re-release of nCaF2 cements did not decrease with increasing the number of recharge and re-release cycles (p > 0.1). A novel F ion-rechargeable orthodontic cement containing nCaF2 was developed with clinically acceptable enamel SBS, good biocompatibility, and sustained F ion recharge and re-release that were 1.8 folds that of a commercial RMGI. Novel rechargeable nCaF2 orthodontic cement is promising to provide the needed long-term and high levels of F ion releases to inhibit WSLs in orthodontics. Copyright © 2019 Elsevier Ltd. All rights reserved.

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