Variations in landscape patterns can provide key information on the effects human activity has on landscapes, and consequently, have received increased attention in recent years. This paper mainly deals with the spatio-temporal variation and driving force of the landscape pattern on the Yancheng coast using remote sensing and GIS. The results indicate the following: (1) The landscape was mostly farmland from 1984 to 2008, not wetlands. The landscape matrix changed from a situation in which the natural landscape was equal to the artificial landscape in 1984, while the latter was dominant between 1990 and 2008. The area of natural landscape decreased considerably—the proportion of natural landscapes was 51.07% in 1984, while it decreased to 28.82% in 2008. Artificial landscapes increased significantly—the majority of the increased artificial landscapes were farmland and aquaculture ponds. (2) The changes in these landscapes showed a trend, changing from natural landscapes to artificial landscapes. Salinity is the decisive factor of this fixed route o the landscape successions of the coast. (3) Although Yancheng wetland nature reserve was established in 1984 and was designated as a National Nature Reserve in 1992, anthropogenic activities on the Yancheng coast continue apace, and the trend of natural landscape loss has not changed. (4) According to the analysis of the landscape transition rate of the Yancheng coast during each phase, we concluded that the main driving force of coastal landscape succession was anthropogenic activities. Our method provides a novel quantitative method to assess the driving forces behind landscape successions.