Affordable Access

Novel PRNP sequence variant associated with familial encephalopathy.

Authors
  • Cervenáková, L
  • Buetefisch, C
  • Lee, H S
  • Taller, I
  • Stone, G
  • Gibbs, C J Jr
  • Brown, P
  • Hallett, M
  • Goldfarb, L G
Type
Published Article
Journal
American journal of medical genetics
Publication Date
Dec 15, 1999
Volume
88
Issue
6
Pages
653–656
Identifiers
PMID: 10581485
Source
Medline
License
Unknown

Abstract

Human transmissible spongiform encephalopathies (TSEs) are a group of chronic progressive neurodegenerative disorders that may be hereditary, infectious, or sporadic. Hereditary TSEs are associated with mutations in the PRNP gene on chromosome 20p12-pter. We report on a family in which seven patients developed limb and truncal ataxia, dysarthria, myoclonic jerks, and cognitive decline. The age of onset in the 30s, 40s, or 50s, prolonged disease duration, cerebellar atrophy on imaging, and the presence of synchronic periodic discharges on electroencephalogram suggested a familial encephalopathy resembling Gerstmann-Sträussler-Scheinker disease. A novel H187R mutation has been identified in affected, but not in unaffected, family members or unrelated controls suggesting a pathogenic role for this mutation. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:653-656, 1999. Published 1999 Wiley-Liss, Inc.

Report this publication

Statistics

Seen <100 times